Publications

Antigonadotropins: A Novel Strategy to Halt Alzheimer's Disease Progression. Gregory CW, Atwood CS, Smith MA, Bowen RL. Curr Pharm Des 12(6):685-90 2006.
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Luteinizing Hormone Modulates Cognition and Amyloid-Β Deposition in Alzheimer APP Transgenic Mice. Casadesus G, Webber KM, Atwood CS, Pappolla MA, Perry G, Bowen R, Smith MA. Biochim Biophys Acta Apr;1762(4):447-52. Epub 2006 Feb 13
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Estrogen Bows to a New Master: The Role of Gonadotropins in Alzheimer Pathogenesis. Webber KM, Casadesus G, Marlatt MW, Hamlin CR, Atwood CS, Perry G, Bowen R, Smith MA. Ann NY Acad Sc 1052: 201-209, 2005.

Gender Differences in Alzheimer Disease: The Role of Luteinizing Hormone in Disease Pathogenesis. Webber KM, Casadesus G, Perry G, Atwood CS, Bowen R, Smith MA. Alzheimer Dis Assoc Discord 19: 2 April-June 2005.
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Novel Therapeutic Strategies for Alzheimer’s Disease Based on the Forgotten Reproductive Hormones. Gregory CW, Bowen RL. Cell Mol Life Sci 62(3):313-319, Feb 2005.
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(PDF 304 KB)

Dementia and Testosterone Levels in Men. Bowen RL, Martins RN, Gregory CW, Smith MA, Atwood CS. JAMA 293(5):551, Feb 2, 2005.

Evidence for the Role of Gonadotropin Hormones in the Development of Alzheimer Disease. Casadesus G, Atwood CS, Zhu X, Hartzler AW, Webber KM, Perry G, Bowen, RL, Smith MA.Cell Mol Life Sci 62(3): 293-38, Feb 2005.
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Feedback on a Feedback Loop: The Hypothalamic-Pituitary-Gonadal axis. Atwood CS, Smith MA, Bowen, RL. J Alzheimers Dis 7(1):1-2, Feb 2005.
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Mechanism Involved in Gender Differences in Alzheimer’s Disease: The Role of Leuteinizing and Follicle Stimulating Hormones. Bowen RL, Atwood CS, Perry G, Smith MA. Principles of Gender-Specific Medicine 112:1234-37, 2004.

Beyond Estrogen: Targeting Gonadotropin Hormones in the Treatment of Alzheimer’s Disease. Casadesus G, Zhu X, Atwood CS, Webber KM, Perry G, Bowen RL, Smith MA Curr Drug Targets-CNS Neurol Disord 3(4): 281-285, 2004.

Mitotic and Gender Parallels in Alzheimer Disease: Therapeutic Opportunities. Zhu X, Webber KM, Casadesus G, Raina AK, Lee HG, Marlatt, Hartzler A, Atwood CS, Bowen R, Perry G, Smith MA. Curr Drug Targets 5:559-563, 2004.
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Sex hormones and ApoE4: Beyond steroids. Bowen RL, Gregory CW. J Alzheimers Dis 6(3):229-230, June 2004.
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Elevated Expression of a Regulator of the G2/M Phase of the Cell Cycle, Neuronal CIP-1-Associated Regulator of Cyclin B, in Alzheimer’s Disease. Zhu X, McShea A, Harris PLR, Raina AK, Castellani RJ, Funk JO, Shah S, Atwood, C, Bowen R, Bowser R, Morelli L, Perry G, Smith MA. J Neurosci Res 75:698-703, 2004.
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(PDF 244 KB)

Gonadotropins and Alzheimer’s Disease: The Link Between Estrogen Replacement Therapy and Neuroprotection. Webber KM, Bowen RL, Casadesus G, Perry G, Atwood, CS, Smith MA. Acta Neurobiol Exp 64:113-118, 2004.
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(PDF 96 KB)

Living and Dying for Sex: A Theory of Aging based on the Modulation of Cell Cycle Signaling by Reproductive Hormones. Bowen RL, Atwood CS Gerontol 50(5):265-290, 2004.
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Luteinizing Hormone, a Reproductive Regulator That Modulates the Processing of Amyloid-beta Precursor Protein and Amyloid-beta Deposition. Bowen R.L, Verdile G, Liu T, Parlow AF, Perry G, Smith MA, Martins R.N, Atwood CS. J Biol Chem 279(19): 20539-20545, May 7, 2004.
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Is the Abeta Vaccine the Answer? Bowen, RL. Neurobiol Aging 25:617-618, May-June 2004.
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Pennington Scientific Symposium on Mechanisms and Retardation of Aging. Exp Gerontol 38(10):1217-1226, Oct 2003.
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Estrogen Replacement and Risk of Alzheimer Disease. Smith MA, Perry G, Atwood CS, Bowen RL. JAMA 289(9):1100; author reply 1101-2; Mar 5, 2003.
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(PDF 112 KB)

Elevated Luteinizing Hormone Expression Colocalizes With Neurons Vulnerable to Alzheimer's Disease Pathology. Bowen RL, Smith MA, Harris PL, Kubat Z, Martins RN, Castellani RJ, Perry G, Atwood CS. J Neurosci Res 70(3):514-518, Nov 1, 2002.
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(PDF 260 KB)

Elevated Gonadotropin Levels in Patients with Alzheimer Disease. Short RA, Bowen RL, O'Brien PC, Graff-Radford NR Mayo Clin Proc 76:906-909, 2001.

An Association of Elevated Serum Gonadotropin Concentrations and Alzheimer Disease? Bowen RL, Isley J, Atkinson RL. J Neuroendocrino 12: 351-354, 2000.
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